Keiichi Kuwano Selected Research

Epoprostenol Receptors

1/2021	[Pharmacological characteristics and clinical study results of Selexipag (Uptravi® tablets), a selective prostacyclin receptor agonist].
1/2020	The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats.
1/2017	A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcine and human pulmonary arteries.
9/2015	Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
9/2008	A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active form, {4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid (MRE-269), on rat pulmonary artery.
11/2007	Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.

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Keiichi Kuwano Research Topics

Disease

6	Pulmonary Arterial Hypertension 01/2021 - 09/2007
2	Right Ventricular Hypertrophy 01/2021 - 09/2008
2	Hypoxia (Hypoxemia) 01/2021 - 01/2020
2	Hypertrophy 01/2020 - 09/2008
2	Vascular Diseases (Vascular Disease) 11/2007 - 09/2007
1	Cardiovascular Diseases (Cardiovascular Disease) 09/2015
1	Pulmonary Hypertension 09/2008
1	Arteriosclerosis Obliterans 09/2007

Drug/Important Bio-Agent (IBA)

6	selexipagIBA 01/2021 - 09/2007
6	Epoprostenol ReceptorsIBA 01/2021 - 11/2007
2	Epoprostenol (Prostacyclin)FDA LinkGeneric 01/2021 - 09/2015
2	Semaxinib (SU5416)IBA 01/2021 - 01/2020
2	acetamideIBA 01/2017 - 09/2008
1	TabletsIBA 01/2021
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2020
1	ProstaglandinsIBA 01/2017
1	MonocrotalineIBA 09/2008
1	Acetic Acid (Vinegar)FDA LinkGeneric 09/2008
1	ProdrugsIBA 09/2008
1	Pharmaceutical PreparationsIBA 09/2007

Therapy/Procedure

1	Oral Administration 01/2020